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Drosophila Perpetuates Nutritional Mutualism by Promoting the Fitness of Its Intestinal Symbiont Lactobacillus plantarum.
Cell Metabolism ( IF 27.7 ) Pub Date : 2018-Feb-06 , DOI: 10.1016/j.cmet.2017.11.011 Gilles Storelli 1 , Maura Strigini 1 , Théodore Grenier 1 , Loan Bozonnet 1 , Martin Schwarzer 1 , Catherine Daniel 2 , Renata Matos 1 , François Leulier 1
Cell Metabolism ( IF 27.7 ) Pub Date : 2018-Feb-06 , DOI: 10.1016/j.cmet.2017.11.011 Gilles Storelli 1 , Maura Strigini 1 , Théodore Grenier 1 , Loan Bozonnet 1 , Martin Schwarzer 1 , Catherine Daniel 2 , Renata Matos 1 , François Leulier 1
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Facultative animal-bacteria symbioses, which are critical determinants of animal fitness, are largely assumed to be mutualistic. However, whether commensal bacteria benefit from the association has not been rigorously assessed. Using a simple and tractable gnotobiotic model- Drosophila mono-associated with one of its dominant commensals, Lactobacillus plantarum-we reveal that in addition to benefiting animal growth, this facultative symbiosis has a positive impact on commensal bacteria fitness. We find that bacteria encounter a strong cost during gut transit, yet larvae-derived maintenance factors override this cost and increase bacterial population fitness, thus perpetuating symbiosis. In addition, we demonstrate that the maintenance of the association is required for achieving maximum animal growth benefits upon chronic undernutrition. Taken together, our study establishes a prototypical case of facultative nutritional mutualism, whereby a farming mechanism perpetuates animal-bacteria symbiosis, which bolsters fitness gains for both partners upon poor nutritional conditions.
中文翻译：
果蝇通过促进其肠道共生植物乳杆菌的适应性来维持营养互惠。
兼性动物-细菌共生是动物适应性的关键决定因素，在很大程度上被认为是互惠的。但是，尚未严格评估共生细菌是否从该关联中受益。使用简单易处理的gnotobiotic模型（果蝇与其主要优势之一单果蝇乳酸菌（Lactobacillus plantarum）单关联），我们发现，除了有利于动物的生长外，这种兼性共生还对共有细菌的适应性产生了积极影响。我们发现细菌在肠道运输过程中遇到了高昂的成本，但幼虫衍生的维持因子却超过了这一成本并增加了细菌种群的适应性，从而使共生永久化。此外，我们证明了维持协会对于在慢性营养不良时实现最大的动物生长效益是必需的。
更新日期：2017-12-31
中文翻译：
果蝇通过促进其肠道共生植物乳杆菌的适应性来维持营养互惠。
兼性动物-细菌共生是动物适应性的关键决定因素，在很大程度上被认为是互惠的。但是，尚未严格评估共生细菌是否从该关联中受益。使用简单易处理的gnotobiotic模型（果蝇与其主要优势之一单果蝇乳酸菌（Lactobacillus plantarum）单关联），我们发现，除了有利于动物的生长外，这种兼性共生还对共有细菌的适应性产生了积极影响。我们发现细菌在肠道运输过程中遇到了高昂的成本，但幼虫衍生的维持因子却超过了这一成本并增加了细菌种群的适应性，从而使共生永久化。此外，我们证明了维持协会对于在慢性营养不良时实现最大的动物生长效益是必需的。
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