The relative and absolute configurations of an oxygenated bisabolane natural product, isolated from Ligularia lankongensis, were determined by synthesis. All four possible stereoisomers and their tiglate analogues were synthesized from R-(−)-carvone, and their ¹H and ¹³C NMR spectra were compared to establish the 6R,8S,10S configuration. The stereoselective synthesis of the natural product was also achieved, featuring Brown allylation, vanadium-catalyzed epoxidation, and the Mitsunobu reaction.

中文翻译：

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高度氧化Bisabolane倍半萜从隔离的全合成橐lankongensis天然产物的相对和绝对构型：

含氧bisabolane天然产品的相对和绝对构型中，从分离橐lankongensis，被合成来确定。从R -（-）-香芹酮合成了所有四种可能的立体异构体及其tiglate类似物，并比较了它们的¹ H和¹³ C NMR光谱以建立6 R，8 S，10 S构型。还实现了天然产物的立体选择性合成，其特征在于布朗烯丙基化，钒催化的环氧化和Mitsunobu反应。