Three novel cyclodepsipeptides, alveolarides A (1), B (2), and C (3), each possessing the rare 2,3-dihydroxy-4-methyltetradecanoic acid unit and a β-phenylalanine amino acid residue, along with the known peptide scopularide were isolated and identified from the culture broth of Microascus alveolaris strain PF1466. The pure compounds were evaluated for biological activity, and alveolaride A (1) provided strong in vitro activity against the plant pathogens Pyricularia oryzae, Zymoseptoria tritici, and Ustilago maydis. Moderate activity of alveolaride A was observed under in planta conditions against Z. tritici, Puccinia triticina, and Phakopsora pachyrhizi. Structures of 1, 2, and 3 were determined by detailed analysis of NMR (1D and 2D) and mass spectrometry data. The partial absolute configuration of alveolaride A (1) was established.

中文翻译：

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肺泡酰胺类：来自微囊藻的抗真菌肽，对植物致病真菌具有活性

三个新型环二肽，肺泡酰胺A（1），B（2）和C（3），每个都具有稀有的2,3-二羟基-4-甲基十四烷酸单元和β-苯丙氨酸氨基酸残基，以及已知的肽从Microascus alveolaris菌株PF1466的培养液中分离并鉴定了scopularide。对纯化合物的生物活性进行了评估，并且alveolaride A（1）在体外对植物病原体Pyricularia oryzae，Zymoseptoria tritici和Ustilago maydis具有很强的体外活性。在植物体内观察到中等程度的肺泡素A活性对抗Z. tritici，Puccinia triticina和Phakopsora pachyrhizi的条件。的结构1，2，和3通过NMR（1D和2D）的详细分析和质谱数据确定。建立了肺泡酰胺A（1）的部分绝对构型。