Novel Multicomponent Synthesis of Pyridine–Pyrimidines and Their Bis-Derivatives Catalyzed by Triazine Diphosphonium Hydrogen Sulfate Ionic Liquid Supported on Functionalized Nanosilica,ACS Combinatorial Science

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Novel Multicomponent Synthesis of Pyridine–Pyrimidines and Their Bis-Derivatives Catalyzed by Triazine Diphosphonium Hydrogen Sulfate Ionic Liquid Supported on Functionalized Nanosilica
ACS Combinatorial Science Pub Date : 2017-12-27 00:00:00 , DOI: 10.1021/acscombsci.7b00079
Fahime Rahmani ₁ , Iraj Mohammadpoor-Baltork ₁ , Ahmad Reza Khosropour ₁ , Majid Moghadam ₁ , Shahram Tangestaninejad ₁ , Valiollah Mirkhani ₁

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In this Research Article, we report an efficient synthesis of 1,3-dimethyl-5-aryl-7-(pyridine-3(2)(4)-yl)pyrimidine-2,4(1H,3H)-diones via a three-component reaction of aryl aldehydes, 1,3-dimethyl-6-aminouracil and carbonitriles in the presences of triazine diphosphonium hydrogen sulfate ionic liquid supported on functionalized nanosilica (APTADPHS-nSiO₂) as a reusable catalyst under microwave irradiation and solvent-free conditions. The bis-derivatives of pyridine–pyrimidines were also efficiently prepared from dialdehydes and dinitriles. In addition, 3-methyl-1H-pyrazole-5-amine was used successfully instead of 1,3-dimethyl-6-aminouracil under the same conditions to afford the corresponding products in high yields. The catalyst can be reused at least five times without any significant loss of its activity. The easy recovery, reusability and excellent activity of the catalyst as well as easy workup are other noteworthy advantages of this method.

中文翻译：

官能化纳米二氧化硅负载三嗪二Di硫酸氢根离子液体催化吡啶-嘧啶及其双衍生物的多组分合成

在这篇研究文章中，我们报告了1,3-二甲基-5-芳基-7-（吡啶-3（2）（4）-基）嘧啶-2,4（1 H，3 H）-二酮的有效合成芳基醛，1,3-二甲基-6-氨基尿嘧啶和腈的三组分反应，在微波辐射下，在可重用催化剂上负载在功能化纳米二氧化硅（APTADPHS- n SiO ₂）上的三嗪二phosph硫酸氢盐离子液体存在下，无溶剂条件。吡啶-嘧啶的双衍生物也可以有效地由二醛和二腈制备。另外，3-甲基-1 H在相同条件下，成功地使用了-吡唑-5-胺代替1,3-二甲基-6-氨基尿嘧啶，从而以高收率提供了相应的产品。催化剂可以重复使用至少五次，而不会显着降低其活性。该催化剂的易于回收，可重复使用性和优异的活性以及易于后处理是该方法的其他值得注意的优点。

更新日期：2017-12-27

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