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Functionalized Flexible Soft Polymer Optical Fibers for Laser Photomedicine
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2017-12-28 , DOI: 10.1002/adom.201701118 Nan Jiang 1, 2 , Rajib Ahmed 3 , Ahmmed A. Rifat 4 , Jingjing Guo 5 , Yixia Yin 2 , Yunuen Montelongo 6, 7 , Haider Butt 3 , Ali K. Yetisen 8, 9, 10
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2017-12-28 , DOI: 10.1002/adom.201701118 Nan Jiang 1, 2 , Rajib Ahmed 3 , Ahmmed A. Rifat 4 , Jingjing Guo 5 , Yixia Yin 2 , Yunuen Montelongo 6, 7 , Haider Butt 3 , Ali K. Yetisen 8, 9, 10
Affiliation
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Optical waveguides allow propagating light through biological tissue in optogenetics and photomedicine applications. However, achieving efficient light delivery to deep tissues for long‐term implantation has been limited with solid‐state optical fibers. Here, a method is created to rapidly fabricate flexible, functionalized soft polymer optical fibers (SPOFs) coupled with silica fibers. A step‐index core/cladded poly(acrylamide‐co‐poly(ethylene glycol) diacrylate)/Ca alginate SPOF is fabricated through free‐radical polymerization in a mold. The SPOF is integrated with a solid‐state silica fiber coupler for efficient light delivery. The cladded SPOF shows ≈1.5‐fold increase in light propagation compared to the noncladded fiber. The optical loss of the SPOF is measured as 0.6 dB cm−1 at the bending angle of 70° and 0.28 dB cm−1 through a phantom tissue. The SPOF (inner Ø = 200 µm) integrated with a 21 gauge needle (inner Ø = 514 µm) is inserted within a porcine tissue. The intensity of light decreases ≈60%, as the SPOF is implanted as deep as 2 cm. Doped with fluorescent dye and gold nanoparticles, the SPOF fiber exhibits yellow‐red and red illumination. Living cells can also be incorporated within the SPOF with viability. The flexible SPOFs may have applications in photodynamic light therapy, optical biosensors, and photomedicine.
中文翻译：
用于激光光医学的功能化柔性软聚合物光纤
光波导允许在光遗传学和光医学应用中通过生物组织传播光。但是，固态光纤无法有效地将光传输到深部组织以进行长期植入。在这里，创造了一种方法来快速制造与二氧化硅纤维耦合的柔性，功能化的软质聚合物光纤（SPOF）。通过在模具中进行自由基聚合来制备阶跃型芯/包层聚（丙烯酰胺-共-聚（乙二醇）二丙烯酸酯）/藻酸钙SPOF。SPOF与固态石英光纤耦合器集成在一起，可实现高效的光传输。与未包覆的光纤相比，包覆的SPOF的光传播增加了约1.5倍。SPOF的光损耗测得为0.6 dB cm -1通过幻影组织以70°的弯曲角度和0.28 dB cm -1弯曲。将与21号针头（内部Ø= 514 µm）集成的SPOF（内部Ø= 200 µm）插入到猪组织内。随着SPOF的植入深度达到2 cm，光强度降低了约60％。掺有荧光染料和金纳米颗粒的SPOF纤维呈现出黄红色和红色的照明。活细胞也可以掺入SPOF中并具有生存力。柔性SPOF可在光动力光疗法，光学生物传感器和光医学中应用。
更新日期：2017-12-28
中文翻译：
用于激光光医学的功能化柔性软聚合物光纤
光波导允许在光遗传学和光医学应用中通过生物组织传播光。但是，固态光纤无法有效地将光传输到深部组织以进行长期植入。在这里，创造了一种方法来快速制造与二氧化硅纤维耦合的柔性，功能化的软质聚合物光纤（SPOF）。通过在模具中进行自由基聚合来制备阶跃型芯/包层聚（丙烯酰胺-共-聚（乙二醇）二丙烯酸酯）/藻酸钙SPOF。SPOF与固态石英光纤耦合器集成在一起，可实现高效的光传输。与未包覆的光纤相比，包覆的SPOF的光传播增加了约1.5倍。SPOF的光损耗测得为0.6 dB cm -1通过幻影组织以70°的弯曲角度和0.28 dB cm -1弯曲。将与21号针头（内部Ø= 514 µm）集成的SPOF（内部Ø= 200 µm）插入到猪组织内。随着SPOF的植入深度达到2 cm，光强度降低了约60％。掺有荧光染料和金纳米颗粒的SPOF纤维呈现出黄红色和红色的照明。活细胞也可以掺入SPOF中并具有生存力。柔性SPOF可在光动力光疗法，光学生物传感器和光医学中应用。
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