Light-Guided Nanomotor Systems for Autonomous Photothermal Cancer Therapy,ACS Applied Materials & Interfaces

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Light-Guided Nanomotor Systems for Autonomous Photothermal Cancer Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1021/acsami.7b16595
Hyunsik Choi ₁ , Geon-Hui Lee ₁ , Ki Su Kim _{2,

3} , Sei Kwang Hahn _{1,

3}

Affiliation

Machines have greatly contributed to the human civilization, enabling tasks beyond our capacities for improved quality of life. Recently, the progress in nanotechnology has triggered to build a miniaturized machine of nanoscale. In this context, synthetic nanomotors have gained considerable interest because of their great promise for diverse applications. Currently, the movement control of these nanomotors has been widely investigated using various stimuli. Here, we demonstrate near-infrared (NIR) light controlled on/off motion of stomatocyte nanomotors powered by the conversion of hydrogen peroxide. The nanomotors encapsulating naphthalocyanine (NC) are aggregated or separated (collective motion) with or without near-IR light illumination, resulting in the well-controlled movement. Remarkably, the nanomotors can move directionally toward hydrogen peroxide released from cancer cells and photothermally ablate the cancer cells. Taken together, our stomatocyte nanomotor systems can be effectively harnessed for autonomous photothermal cancer therapy.

中文翻译：

自主光热癌治疗的光导纳米电机系统

机器为人类文明做出了巨大贡献，使工作超出了我们的能力范围，从而改善了生活质量。近来，纳米技术的进步触发了建造纳米级小型化机器的运动。在这种情况下，合成纳米马达因其在各种应用中的巨大前景而引起了人们的极大兴趣。目前，已经使用各种刺激广泛研究了这些纳米马达的运动控制。在这里，我们演示了由过氧化氢的转化驱动的气道细胞纳米马达的近红外（NIR）光控制开/关运动。封装萘酞菁（NC）的纳米马达在有或没有近红外光照射下会聚集或分离（集体运动），从而导致运动得到很好的控制。值得注意的是纳米马达可以朝着从癌细胞释放的过氧化氢方向移动，并光热切除癌细胞。综上所述，我们的口腔细胞纳米电机系统可以有效地用于自主的光热癌症治疗。

更新日期：2018-01-12

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