当前位置: X-MOL 学术J. Am. Chem. Soc. › 论文详情
Deformable Hollow Periodic Mesoporous Organosilica Nanocapsules for Significantly Improved Cellular Uptake
Journal of the American Chemical Society ( IF 14.357 ) Pub Date : 2018-01-03 , DOI: 10.1021/jacs.7b10694
Zhaogang Teng, Chunyan Wang, Yuxia Tang, Wei Li, Lei Bao, Xuehua Zhang, Xiaodan Su, Fan Zhang, Junjie Zhang, Shouju Wang, Dongyuan Zhao, Guangming Lu

Mesoporous solids have been widely used in various biomedical areas such as drug delivery and tumor therapy. Although deformability has been recognized as a prime important characteristic influencing cellular uptake, the synthesis of deformable mesoporous solids is still a great challenge. Herein, deformable thioether-, benzene-, and ethane-bridged hollow periodic mesoporous organosilica (HPMO) nanocapsules have successfully been synthesized for the first time by a preferential etching approach. The prepared HPMO nanocapsules possess uniform diameters (240–310 nm), high surface areas (up to 878 m2·g–1), well-defined mesopores (2.6–3.2 nm), and large pore volumes (0.33–0.75 m3·g–1). Most importantly, the HPMO nanocapsules simultaneously have large hollow cavities (164–270 nm), thin shell thicknesses (20–38 nm), and abundant organic moiety in the shells, which endow a lower Young’s modulus (EY) of 3.95 MPa than that of solid PMO nanoparticles (251 MPa). The HPMOs with low EY are intrinsically flexible and deformable in the solution, which has been well-characterized by liquid cell electron microscopy. More interestingly, it is found that the deformable HPMOs can easily enter into human breast cancer MCF-7 cells via a spherical-to-oval morphology change, resulting in a 26-fold enhancement in cellular uptake (43.1% cells internalized with nanocapsules versus 1.65% cells with solid counterparts). The deformable HPMO nanocapsules were further loaded with anticancer drug doxorubicin (DOX), which shows high killing effects for MCF-7 cells, demonstrating the promise for biomedical applications.
更新日期:2018-01-03

 

分享到
评论: 0
期刊列表
nature
Nature
Nature
中国科学院化学研究所有机固体实验室江浪研究员课题组招聘有机电子学博士后
中山大学化学工程与技术学院诚聘腐蚀与防护相关专业人才
【问答】请问电活性物质如亚甲基蓝、硫堇等是否可以既被氧化又被还原?
天合科研
2017年中科院JCR分区化学大类列表
试剂库存管理
化合物查询
down
wechat
bug