Phenanthrenes: A Promising Group of Plant Secondary Metabolites,Journal of Natural Products

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Phenanthrenes: A Promising Group of Plant Secondary Metabolites
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-12-27 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00619
Barbara Tóth ₁ , Judit Hohmann _{1,

2} , Andrea Vasas ₁

Affiliation

Although phenanthrenes are considered to constitute a relatively small group of natural products, discovering new phenanthrene derivatives and evaluating their prospective biological activities have become of great interest to many research groups worldwide. Based on 160 references, this review covers the phytochemistry and pharmacology of 213 naturally occurring phenanthrenes that have been isolated between 2008 and 2016. More than 40% of the 450 currently known naturally occurring phenanthrenes were identified during this period. The family Orchidaceae is the most abundant source of these compounds, although several new plant families and genera have been involved in the search for phenanthrenes. The presence of certain substituent patterns may be restricted to specific families; vinyl-substituted phenanthrenes were reported only from Juncaceae plants, and prenylated derivatives occur mainly in Euphorbiaceae species. Therefore, these compounds also can serve as chemotaxonomic markers. Almost all of the newly isolated compounds have been studied for their biological activities (e.g., potential cytotoxic, antimicrobial, anti-inflammatory, and antioxidant effects), and many of them showed multiple activities. According to the accumulated data, denbinobin, with a novel mechanism of action, has great potential as a lead compound for the development of a new anticancer agent.

中文翻译：

菲：植物次生代谢物的一个有前途的组

尽管菲被认为构成了相对较小的天然产物，但是发现新的菲衍生物并评估其预期的生物活性已成为全世界许多研究小组的极大兴趣。基于160篇参考文献，本综述涵盖了2008年至2016年间分离出的213种天然存在的菲的植物化学和药理作用。在此期间，鉴定出了450种目前已知的天然存在的菲中的40％以上。兰花科是这些化合物的最丰富来源，尽管一些新的植物科和属已经参与了对菲的寻找。某些取代基的存在可能限于特定的家族；仅从菊科植物中报道了乙烯基取代的菲，并且烯丙基化的衍生物主要存在于大戟科物种中。因此，这些化合物也可以用作化学分类标记。已对几乎所有新分离出的化合物的生物学活性（例如潜在的细胞毒性，抗微生物，抗炎和抗氧化作用）进行了研究，其中许多具有多种活性。根据积累的数据，具有新的作用机理的树皮菌素作为开发新的抗癌药的先导化合物具有巨大的潜力。潜在的细胞毒性，抗微生物，抗炎和抗氧化作用），其中许多具有多种活性。根据积累的数据，具有新的作用机理的树皮菌素作为开发新的抗癌药的先导化合物具有巨大的潜力。潜在的细胞毒性，抗微生物，抗炎和抗氧化作用），其中许多具有多种活性。根据积累的数据，具有新的作用机理的树皮菌素作为开发新型抗癌药的先导化合物具有巨大的潜力。

更新日期：2017-12-27

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