Germacrane-Type Sesquiterpenoids with Antiproliferative Activities from Eupatorium chinense,Journal of Natural Products

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Germacrane-Type Sesquiterpenoids with Antiproliferative Activities from Eupatorium chinense
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-12-27 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00693
Xiaoqin Yu _{1,

2} , Qingqing Zhang ₁ , Li Tian ₁ , Zhiyong Guo ₁ , Chengxiong Liu ₁ , Jianfeng Chen ₁ , Weaam Ebrahim _{2,

3} , Zhen Liu ₂ , Peter Proksch ₂ , Kun Zou ₁

Affiliation

Ten new germacrane-type sesquiterpenoids (1–10) were isolated from a whole plant extract of Eupatorium chinense. The structures were elucidated by analysis of their NMR and MS data as well as by comparison with literature values. The absolute configuration of eupachinsin A (1) was determined by single-crystal X-ray diffraction analysis. Compounds 3 and 4 exhibited cytotoxicity against a human breast cancer cell line (MDA-MB-231), with IC₅₀ values of 0.8 and 3.4 μM, respectively. In addition, compounds 3–5 showed cytotoxicity against the human hepatocellular carcinoma cell line (HepG₂), with IC₅₀ values ranging from 3.6 to 7.6 μM.

中文翻译：

吉马烷型倍半萜类与抗增殖活性多须公

十个新吉马烷型倍半萜（1 - 10）从的整株植物提取物中分离多须公。通过分析其NMR和MS数据以及与文献值进行比较来阐明其结构。通过单晶X射线衍射分析确定了Eupachinsin A（1）的绝对构型。化合物3和4对人乳腺癌细胞系（MDA-MB-231）表现出细胞毒性，IC ₅₀值分别为0.8和3.4μM。此外，化合物3 - 5对人肝癌细胞株显示出细胞毒性（人肝癌HepG ₂），IC ₅₀值范围从3.6到7.6μM。

更新日期：2017-12-27

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