Legume lectins are carbohydrate-binding proteins of non-immune origin. Significant amounts of lectins have been found in Phaseolus vulgaris beans as far back as in the last century; however, many questions about their potential biological roles still remain obscure. Studies have shown that lectins are anti-nutritional factors that can cause intestinal disorders. Owing to their ability to act as toxic allergens and hemagglutinins, the Phaseolus vulgaris lectins are of grave concern for human health and safety. Nonetheless, their potential beneficial health effects, such as anti-cancer, anti-human immunodeficiency virus (anti-HIV), anti-microbial infection, preventing mucosal atrophy, reducing type 2 diabetes and obesity, promoting nutrients absorption and targeting drugs, are of immense interest. The significance of Phaseolus vulgaris lectins in biological researches and the potential biomedical applications have placed tremendous emphasis on the development of purification strategies to obtain the protein in pure and stable forms. These purification strategies entail considerations such as effects of proteolysis, heating, gamma radiation, and high-hydrostatic-pressure that can have crucial outcomes in either eliminating or improving bioactivities of the lectins. Thus, up-to-date research findings of Phaseolus vulgaris lectins on different aspects such as anti-nutritional and health impacts, purification strategies and novel processing trends, are systematically reviewed.

中文翻译：

---

菜豆植物凝集素：特征和对健康的系统评价

豆科植物凝集素是非免疫起源的碳水化合物结合蛋白。早在上个世纪，在菜豆中就发现了大量的凝集素。但是，关于其潜在生物学作用的许多问题仍然不清楚。研究表明，凝集素是可以引起肠道疾病的抗营养因子。菜豆凝集素由于具有毒性过敏原和血凝素的功能，因此对人类健康和安全至关重要。但是，它们具有潜在的有益健康作用，例如抗癌，抗人类免疫缺陷病毒（anti-HIV），抗微生物感染，预防粘膜萎缩，减少2型糖尿病和肥胖症，促进营养吸收和靶向药物。极大的兴趣。菜豆凝集素在生物学研究中的重要性以及潜在的生物医学应用已极大地强调了开发纯化策略以获得纯净和稳定形式蛋白质的方法。这些纯化策略需要考虑诸如蛋白水解，加热，伽马辐射和高静水压力的影响，这些对消除或改善凝集素的生物活性可能具有至关重要的结果。因此，系统地回顾了菜豆凝集素在不同方面的最新研究成果，例如抗营养和健康影响，纯化策略和新颖的加工趋势。