The successful regeneration of bone tissue to replace areas of bone loss in large defects or at load‐bearing sites remains a significant clinical challenge. Over the past few decades, major progress is achieved in the field of bone tissue engineering to provide alternative therapies, particularly through approaches that are at the interface of biology and engineering. To satisfy the diverse regenerative requirements of bone tissue, the field moves toward highly integrated approaches incorporating the knowledge and techniques from multiple disciplines, and typically involves the use of biomaterials as an essential element for supporting or inducing bone regeneration. This review summarizes the types of approaches currently used in bone tissue engineering, beginning with those primarily based on biology or engineering, and moving into integrated approaches in the areas of biomaterial developments, biomimetic design, and scalable methods for treating large or load‐bearing bone defects, while highlighting potential areas for collaboration and providing an outlook on future developments.

中文翻译：

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当前骨组织工程学方法：生物学与工程学之间的接口

骨组织的成功再生以替代大缺陷或承重部位的骨丢失区域仍然是一项重大的临床挑战。在过去的几十年中，在骨组织工程领域提供了替代疗法，尤其是通过生物学和工程学界的方法，取得了重大进展。为了满足骨骼组织的各种再生需求，该领域朝着整合了来自多个学科的知识和技术的高度集成的方法发展，并且通常涉及使用生物材料作为支持或诱导骨骼再生的基本要素。这篇综述总结了目前在骨组织工程中使用的各种方法，首先是基于生物学或工程学的方法，