Tension‐Activated Delivery of Small Molecules and Proteins from Superhydrophobic Composites,Advanced Healthcare Materials

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Tension‐Activated Delivery of Small Molecules and Proteins from Superhydrophobic Composites
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-12-27 , DOI: 10.1002/adhm.201701096
Julia Wang ₁ , Yolonda L Colson ₂ , Mark W Grinstaff ₁

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The fabrication and performance of mechanically responsive multilayer superhydrophobic composites are reported. The application of tensile strain triggers the release of small molecules and proteins from these composites, with different tensile strain magnitudes and coating thickness influencing agent release. These mechanoresponsive composites consist of an absorbent drug core surrounded by an electrosprayed superhydrophobic protective coating that limits drug release in the absence of tensile strain. Coating thickness and applied tensile strain control release of chemotherapeutic cisplatin and enzyme β‐galactosidase, as measured by atomic absorption and UV–vis spectrophotometry, respectively, with preserved in vitro activity. Such mechanically responsive drug delivery devices, when coupled to existing dynamic mechanical forces in the body or integrated with mechanical medical devices, such as stents, will provide local controlled dosing.

中文翻译：

超疏水复合材料中小分子和蛋白质的张力激活传递

报道了机械响应多层超疏水复合材料的制造和性能。施加拉伸应变会触发这些复合材料中小分子和蛋白质的释放，不同的拉伸应变大小和涂层厚度会影响药剂的释放。这些机械响应复合材料由吸收性药物核心组成，周围有电喷涂超疏水保护涂层，可在没有拉伸应变的情况下限制药物释放。分别通过原子吸收和紫外可见分光光度法测量，涂层厚度和施加的拉伸应变控制化疗顺铂和酶β-半乳糖苷酶的释放，并保留体外活性。这种机械响应式药物输送装置，当与体内现有的动态机械力耦合或与机械医疗装置（例如支架）集成时，将提供局部控制剂量。

更新日期：2017-12-27

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