Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.

中文翻译：

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持续诱导气道中杯状细胞分化：治疗方法

杯状细胞分化的诱导失调导致粘液的过量产生和滞留，并且是几种慢性气道疾病的共同特征。迄今为止，减少粘液积累的治疗策略主要集中在改变粘液本身的性质上，或旨在限制刺激粘液的细胞因子的产生。在这里，我们回顾了在杯状细胞持续分化过程中失调的关键分子途径的当前知识，并着重介绍了与这种病理学作斗争的既有方法和新颖治疗方法。