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An improved synthesis of 1-methylcyclopropanol using the Kulinkovich reaction
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2017-12-23 , DOI: 10.1016/j.bmc.2017.12.029
Christine Delsarte , Guillaume Etuin , Laurent Petit

An improved process for the preparation of 1-methylcyclopropanol using the Kulinkovich reaction is described. The use of titanium tetramethoxide as catalyst resulted in minimal side product formation. The reaction, isolation and purification procedures were optimized so they can be easily implemented in multi-purpose equipment.



中文翻译:

使用库林科维奇反应改进的1-甲基环丙醇合成

描述了一种使用库林科维奇反应制备1-甲基环丙醇的改进方法。使用四甲醇钛作为催化剂可减少副产物的形成。优化了反应,分离和纯化程序,因此可以轻松地在多功能设备中实施。

更新日期:2017-12-23
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