Methylglyoxal (MG) is a predominant precursor for advanced glycation end products (AGEs) due to its protein glycation reactions, which are the major causes of diabetic complications. MG is explored as a significant biomarker towards the prediction of diabetic complications. With this background, a non-enzymatic electrochemical biosensor has been developed to detect MG in human blood plasma samples. Microwave synthesized V₂O₅ nanoplates were used as interface material in the fabrication of modified gold (Au) working electrode for electrochemical MG biosensor. Orthorhombic crystal structured V₂O₅ with an oxidation state of +5 exhibited specific MG sensing performance. Cyclic voltammetry and amperometry studies confirmed the electrocatalytic nature of V₂O₅ nanoplates modified Au electrode in the detection of MG. Non-enzymatic V₂O₅ modified Au electrode showed a sensitivity of 4.519 µA µM⁻¹ with a linear range of 3–30 µM, limit of detection (LOD) of 0.24 µM, limit of quantification (LOQ) of 0.80 µM and a response time less than 8 s towards MG. The lifetime and percentage recovery of the sensor was found to be 25 days (90%) and 102.5–108.7% respectively.

甲基乙二醛（MG）由于其蛋白质糖基化反应而成为晚期糖基化终产物（AGEs）的主要前体，这是糖尿病并发症的主要原因。MG被认为是预测糖尿病并发症的重要生物标志物。在这种背景下，已经开发出了一种非酶电化学生物传感器来检测人血浆样品中的MG。微波合成的V ₂ O ₅纳米板被用作界面材料，用于电化学MG生物传感器的修饰金（Au）工作电极的制造。斜方晶体结构的V ₂ O ₅+5的氧化态具有特定的MG感测性能。循环伏安法和安培法研究证实了V ₂ O ₅纳米板修饰的Au电极在MG检测中的电催化特性。非酶V ₂ O ₅修饰的Au电极的灵敏度为4.519 µA µM ^-1，线性范围为3–30 µM，检测极限（LOD）为0.24 µM，定量极限（LOQ）为0.80 µM，对MG的响应时间少于8 s。传感器的寿命和回收率分别为25天（90％）和102.5–108.7％。