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Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetic Retinopathy: Relationship with Cardiovascular Biomarkers
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1021/acs.jafc.7b05063 José Antonio González-Correa 1 , María Dolores Rodríguez-Pérez 1 , Lucía Márquez-Estrada 1 , Juan Antonio López-Villodres 1 , José Julio Reyes 1 , Guillermo Rodriguez-Gutierrez 2 , Juan Fernández-Bolaños 2 , José Pedro De La Cruz 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1021/acs.jafc.7b05063 José Antonio González-Correa 1 , María Dolores Rodríguez-Pérez 1 , Lucía Márquez-Estrada 1 , Juan Antonio López-Villodres 1 , José Julio Reyes 1 , Guillermo Rodriguez-Gutierrez 2 , Juan Fernández-Bolaños 2 , José Pedro De La Cruz 1
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The aim of the study was to test the neuroprotective effect of hydroxytyrosol (HT) on experimental diabetic retinopathy. Animals were divided in four groups: (1) control nondiabetic rats, (2) streptozotocin-diabetic rats (DR), (3) DR treated with 1 mg/kg/day p.o. HT, and (4) DR treated with 5 mg/kg/day p.o. HT. Treatment with HT was started 7 days before inducing diabetes and was maintained for 2 months. In the DR group, total area occupied by extracellular matrix was increased, area occupied by retinal cells was decreased; both returned to near-control values in DR rats treated with HT. The number of retinal ganglion cells in DR was significantly lower (44%) than in the control group, and this decrease was smaller after HT treatment (34% and 9.1%). Linear regression analysis showed that prostacyclin, platelet aggregation, peroxynitrites, and the dose of 5 mg/kg/day HT significantly influenced retinal ganglion cell count. In conclusion, HT exerted a neuroprotective effect on diabetic retinopathy, and this effect correlated significantly with changes in some cardiovascular biomarkers.
中文翻译：
羟基酪醇在实验性糖尿病视网膜病变中的神经保护作用：与心血管生物标志物的关系。
这项研究的目的是测试羟基酪醇（HT）对实验性糖尿病视网膜病变的神经保护作用。将动物分为四组：（1）对照非糖尿病大鼠，（2）链脲佐菌素-糖尿病大鼠（DR），（3）用1 mg / kg /天po HT处理的DR，和（4）用5 mg / kg处理的DR公斤/天po HT。在诱发糖尿病前7天开始用HT治疗，并维持2个月。在DR组中，细胞外基质占总面积增加，视网膜细胞占总面积减少。在用HT治疗的DR大鼠中，两者均恢复到接近控制值。DR中的视网膜神经节细胞数量显着低于对照组（44％），而HT治疗后这一减少较小（34％和9.1％）。线性回归分析显示前列环素，血小板聚集，过氧亚硝酸盐，5毫克/千克/天的HT剂量显着影响视网膜神经节细胞计数。总之，HT对糖尿病性视网膜病变具有神经保护作用，并且这种作用与某些心血管生物标志物的变化显着相关。
更新日期：2018-01-10
中文翻译：
羟基酪醇在实验性糖尿病视网膜病变中的神经保护作用：与心血管生物标志物的关系。
这项研究的目的是测试羟基酪醇（HT）对实验性糖尿病视网膜病变的神经保护作用。将动物分为四组：（1）对照非糖尿病大鼠，（2）链脲佐菌素-糖尿病大鼠（DR），（3）用1 mg / kg /天po HT处理的DR，和（4）用5 mg / kg处理的DR公斤/天po HT。在诱发糖尿病前7天开始用HT治疗，并维持2个月。在DR组中，细胞外基质占总面积增加，视网膜细胞占总面积减少。在用HT治疗的DR大鼠中，两者均恢复到接近控制值。DR中的视网膜神经节细胞数量显着低于对照组（44％），而HT治疗后这一减少较小（34％和9.1％）。线性回归分析显示前列环素，血小板聚集，过氧亚硝酸盐，5毫克/千克/天的HT剂量显着影响视网膜神经节细胞计数。总之，HT对糖尿病性视网膜病变具有神经保护作用，并且这种作用与某些心血管生物标志物的变化显着相关。
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