Vitex rotundifolia is the variant of the traditional Chinese medicine (TCM) Vitex trifolia. Diterpenoids from V. trifolia have shown anti-hyperlipidemia activity. As part of a continuous research program of searching for anti-hyperlipidemia constituents from TCM, 95% alcohol extract of the fruits of V. rotundifolia was fully studied, and 18 diterpenoids were isolated, including eight previously undescribed compounds (viterofolins A-H). Among them, viterofolins A-B were previously undescribed rearranged halimane-type diterpenoids, viterofolins CH were previously undescribed halimane-type diterpenoids. These compounds were then firstly evaluated in lipid (Dil-LDL) uptake assay in HepG2 cells. Viterofolin H, (5S, 6R, 8R, 9R, 10S)-6-acetoxy-9-hydroxy-13 (14)-labden-16,15-olide and previtexilactone showed moderate activities in promoting LDL uptake (1.27-1.35 fold). This work laid the foundation for searching anti-hyperlipidemia natural products.

中文翻译：

---

圆叶牡荆中的卤烷型二萜及其抗高血脂活性

Vitex rotundifolia 是中药 (TCM) Vitex trifolia 的变种。来自三叶草的二萜类化合物已显示出抗高脂血症的活性。作为从中药中寻找抗高脂血症成分的持续研究计划的一部分，对圆叶圆叶果实的 95% 酒精提取物进行了全面研究，并分离出了 18 种二萜，包括 8 种以前未描述的化合物（viterofolins AH）。其中，viterofolins AB 是以前未描述的重排卤烷型二萜，viterofolins CH 是以前未描述的卤烷型二萜。然后首先在 HepG2 细胞中的脂质 (Dil-LDL) 摄取测定中评估这些化合物。Viterofolin H, (5S, 6R, 8R, 9R, 10S)-6-acetoxy-9-hydroxy-13 (14)-labden-16,15-olide 和 previtexilactone 在促进 LDL 摄取方面表现出中等活性 (1. 27-1.35 倍）。该工作为寻找抗高脂血症天然产物奠定了基础。