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Polycyclic polyprenylated acylphloroglucinols and biphenyl derivatives from the roots of Garcinia nuntasaenii Ngerns. & Suddee
Phytochemistry ( IF 3.2 ) Pub Date : 2018-02-01 , DOI: 10.1016/j.phytochem.2017.12.001
Suppisak Chaturonrutsamee , Chutima Kuhakarn , Panida Surawatanawong , Samran Prabpai , Palangpon Kongsaeree , Thaworn Jaipetch , Pawinee Piyachaturawat , Surawat Jariyawat , Radeekorn Akkarawongsapat , Kanoknetr Suksen , Jitra Limthongkul , Chanita Napaswad , Narong Nuntasaen , Vichai Reutrakul

Seven previously undescribed compounds, including three polycyclic polyprenylated acylphloroglucinols (garcinuntins A-C), three biphenyl derivatives (garcinuntabiphenyls A-C) and a lanostane triterpene (garcinuntine), along with thirteen known compounds were isolated from the root of Garcinia nuntasaenii Ngerns. & Suddee. Their structures were elucidated on the basis of spectroscopic techniques. For garcinuntins A-C, the absolute configurations were confirmed by the combination of single X-ray crystallography and ECD calculations. Anti-HIV activity using anti-HIV-1 reverse transcriptase and syncytium inhibition assays, and cytotoxic activity against a panel of cultured mammalian cancer cell lines of isolated compounds were investigated.

中文翻译:

来自 Garcinia nuntasaenii Ngerns 根的多环聚异戊二烯化酰基间苯三酚和联苯衍生物。&苏迪

从 Garcinia nuntasaenii Ngerns 的根中分离出 7 种以前未描述的化合物,包括三种多环聚异戊二烯化酰基间苯三酚 (garcinuntins AC)、三种联苯衍生物 (garcinuntabiphenyls AC) 和羊毛甾烷三萜 (garcinuntine),以及 13 种已知化合物。& 苏迪。它们的结构是在光谱技术的基础上阐明的。对于 garcinuntins AC,通过单 X 射线晶体学和 ECD 计算的组合证实了绝对构型。研究了使用抗 HIV-1 逆转录酶和合胞体抑制测定的抗 HIV 活性,以及​​针对一组培养的哺乳动物癌细胞系的分离化合物的细胞毒活性。
更新日期:2018-02-01
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