The search for more efficient and less aggressive cancer treatment methods has intensified over the last decades and has involved many scientific areas. To provide skin cancer patients with better quality of life, this work aims to incorporate chemotherapy into polyamide membranes, functionalized by the sol–gel methodology, for controlled drug release at the target tissue. A 200-micrometer-thick flexible polyamide membrane prepared by Additive Manufacture was activated and functionalized with the alkoxide 3-chloropropyltriethoxysilane, which was followed by incorporation of the antitumor agent cisplatin. Membrane functionalization with the alkoxide was attested by infrared absorption spectroscopy, which evidenced a band at 1100 cm^− 1, due to Si-O-Si vibration, and typical cisplatin bands at 3200 and 1600 cm^− 1. The thermogravimetric curve revealed increased silicon oxide and platinum residues. Drug release was tested in simulated body fluid. Cytotoxicity was evaluated by the Cell Proliferation Kit, which gave IC₅₀ of 23.95 μgM.

在过去的几十年中，对更有效，更不具侵略性的癌症治疗方法的探索日益激烈，并且涉及许多科学领域。为了为皮肤癌患者提供更好的生活质量，这项工作旨在将化学疗法纳入聚酰胺膜中，并通过溶胶-凝胶法对其功能进行控制，以控制药物在靶组织中的释放。将由Additive Manufacture制备的200微米厚的柔性聚酰胺膜活化，并用醇盐3-氯丙基三乙氧基硅烷官能化，然后加入抗肿瘤药顺铂。通过红外吸收光谱法证明了用醇盐进行的膜功能化，这表明由于Si-O-Si振动，在1100 cm ^-1处有一个谱带，在3200和1600 cm处有典型的顺铂谱带。^{− 1}。热重曲线显示出增加的氧化硅和铂残留物。在模拟体液中测试了药物释放。通过细胞增殖试剂盒评估细胞毒性，得到的IC ₅₀为23.95μgM。