Indoor Residual Spraying (IRS), the use of insecticides inside residences for malaria control, may cause elevated exposure to insecticides such as dichlorodiphenyl trichloroethane (DDT). Evidence suggests that DDT exposure may increase blood pressure but no study has investigated associations with hypertensive disorders of pregnancy (HDP) in an IRS area. We measured the serum concentration of DDT and its breakdown product dichlorodiphenyl trichloroethylene (DDE) at the time of delivery among 733 rural South African women participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE). We also collected data on HDP diagnosis through questionnaires administered to participants and medical record abstraction. We used multiple logistic regression models to examine the relation between DDT/E and HDP. p,p′-DDT and p,p′-DDE serum concentrations were associated with HDP based on self-report (OR = 1.50; 95%CI = 1.10, 2.03 for p,p′-DDT and OR = 1.58; 95%CI = 1.09, 2.28 for p,p′-DDE) and medical records (OR = 1.32; 95%CI = 0.99, 1.75 for p,p′-DDT and OR = 1.47; 95%CI = 1.03, 2.09 for p,p′-DDE). p,p′-DDE was also associated with gestational hypertension (OR = 1.44; 95% CI = 1.00, 2.07). Exposure to DDT and DDE may be associated with elevated risks of HDP in South African women residing in an area sprayed for malaria control.

室内残留喷洒（IRS）是在住宅内使用杀虫剂控制疟疾，可能会增加对二氯二苯基三氯乙烷（DDT）等杀虫剂的暴露。有证据表明，DDT暴露可能会导致血压升高，但是尚无研究调查与IRS地区妊娠高血压疾病（HDP）的相关性。我们在分娩时对参与母亲，婴儿及其环境的Venda健康检查的733名南非农村妇女中的滴滴涕及其分解产物二氯二苯基三氯乙烯（DDE）的血清浓度进行了测量。我们还通过对参与者进行的问卷调查和病历提取来收集有关HDP诊断的数据。我们使用了多个逻辑回归模型来检验DDT / E与HDP之间的关系。P，P'- DDT和P，P' -DDE血清浓度是基于自我报告（OR = 1.50与HDP相关联; 95％CI = 1.10，2.03 P，P' p'-DDT和OR = 1.58; 95％ CI = 1.09，p， p'-DDE为2.28 ）或病历（OR = 1.32; 95％CI = 0.99，p，p'- DDT为1.75; OR = 1.47; 95％CI = 1.03，p为2.09 ， p' -DDE）。p， p'-DDE也与妊娠高血压有关（OR = 1.44; 95％CI = 1.00，2.07）。在为控制疟疾而喷洒喷雾的地区居住的南非妇女中，接触DDT和DDE可能与HDP风险升高有关。