There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that compartmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent powder mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space.

在高剪切造粒中，需要中尺度分辨率以及流场信息与颗粒特性演变之间的耦合。我们已经开发了一个建模框架，可以根据时间和空间上的相关工艺参数，对高剪切造粒工艺进行划分。该模型包括耦合流场和总体平衡求解器，用于解析和分析中尺度对粒子特性演化的影响。使用微晶纤维素粉末作为制粒材料对Diosna高剪切混合机进行建模。对流场解决方案和分隔进行分析可以解决叶轮叶片上的应力和碰撞峰。不同的分隔显示了解决叶轮区域的重要性，用于聚集系统和有破损的系统。一项独立研究通过改变代表粉末混合，初始制粒阶段混合和后期颗粒混合的三个离散步骤更改了颗粒特性，研究了流场的时间演变。时间分辨率研究的结果表明，碰撞行为发生了明显的变化，尤其是从粉末到颗粒的混合，这表明了解决时空中尺度现象的重要性。