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Base‐Promoted Tandem Cyclization for the Synthesis of Benzonitriles by C−C Bond Construction
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-01-15 , DOI: 10.1002/adsc.201701329 Cheng-Zhi Zhu 1 , Yin Wei 2 , Min Shi 1, 2, 3
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-01-15 , DOI: 10.1002/adsc.201701329 Cheng-Zhi Zhu 1 , Yin Wei 2 , Min Shi 1, 2, 3
Affiliation
A facile synthesis of benzonitriles via a base‐promoted tandem cyclization reaction of α,β‐unsaturated enones having electron‐withdrawing group (EWG) and 2‐acyl‐acrylonitriles was developed. This new synthetic method to access benzonitriles is suitable for a wide range of substrates. A plausible reaction mechanism is proposed on the basis of previous literature and our own investigations.
中文翻译:
碱促进的串联环化,通过CC键构建苯甲腈的合成
通过碱促进的具有吸电子基团(EWG)的α,β-不饱和烯酮和2酰基丙烯腈的串联促进环化反应,可以轻松合成苯甲腈。这种获取苯甲腈的新合成方法适用于多种底物。在先前的文献和我们自己的研究的基础上,提出了一种合理的反应机理。
更新日期:2018-01-15
中文翻译:
碱促进的串联环化,通过CC键构建苯甲腈的合成
通过碱促进的具有吸电子基团(EWG)的α,β-不饱和烯酮和2酰基丙烯腈的串联促进环化反应,可以轻松合成苯甲腈。这种获取苯甲腈的新合成方法适用于多种底物。在先前的文献和我们自己的研究的基础上,提出了一种合理的反应机理。