Background

Q-switched alexandrite lasers (QSALs) have been used for the treatment of acquired bilateral nevus of Ota–like macules (ABNOMs). Currently, picosecond alexandrite laser (PSAL) pulses have become available for pigmentary disorders. However, no studies have compared PSAL and QSAL in the treatment of ABNOM.

Objective

We sought to compare the efficacy and safety of PSAL and QSAL in the treatment of ABNOM.

Methods

Each patient (n = 30) received 3 treatments at 6-month intervals. Matching areas were delimitated on the face of each patient (left/right comparison); 1 side was treated with PSAL and the other side was treated with QSAL. The safety and efficacy of the 2 lasers were determined by visual assessment and self-report from patients 6 months after the final treatment.

Results

The PSAL-treated area achieved significantly better clearance (3.73 vs 2.4) with less severe pain (4.47 vs 5.16). The incidence rate of postinflammatory hyperpigmentation was 27.77% and 54.44% for the PSAL and QSAL treatments, respectively, and the duration of postinflammatory hyperpigmentation was 1.32 and 1.74 months, respectively (P < .001).

Limitations

The limitations of our study include the small sample size and the lack of objective evaluation.

Conclusion

Compared with QSAL, PSAL therapy afforded significantly better clinical outcomes and fewer side effects in the treatment of ABNOM.

中文翻译：

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亚历山大单石755 nm皮秒激光与亚历山大石755 nm纳秒激光的裂口，单盲，随机对照比较用于治疗获得性太田样黄斑的双侧痣

背景

调Q变绿宝石激光器（QSAL）已用于治疗获得性太田样黄斑（ABNOM）的双侧痣。目前，皮秒变青变石激光（PSAL）脉冲已可用于色素性疾病。但是，尚无研究比较PSAL和QSAL在ABNOM的治疗中。

客观的

我们试图比较PSAL和QSAL治疗ABNOM的疗效和安全性。

方法

每位患者（n = 30）每6个月接受3次治疗。在每个患者的面部划定匹配区域（左/右比较）；一侧用PSAL处理，另一侧用QSAL处理。在最终治疗后6个月，通过视觉评估和患者自我报告，确定了这两种激光的安全性和有效性。

结果

PSAL治疗区域的清除率明显提高（3.73对2.4），严重疼痛减轻（4.47对5.16）。PSAL和QSAL治疗的炎症后色素沉着的发生率分别为27.77％和54.44％，炎症后色素沉着的持续时间分别为1.32和1.74个月（P  <.001）。

局限性

我们研究的局限性包括样本量小和缺乏客观评估。

结论

与QSAL相比，PSAL治疗在ABNOM的治疗中具有显着更好的临床效果和更少的副作用。