This study investigated how the properties of a polymeric can coating film, such as thickness and crosslink density as well as the type of migrant, influence the migration kinetics of model migrants in an attempt to better understand, model and control the migration process. Four model migrants were used BADGE (bisphenol A diglycidyl ether), BADGE·H₂O, cyclo-diBADGE and Uvitex OB, that differ in size and polarity. Fatty and aqueous food simulants were used at high temperatures (70–130 °C). The apparent diffusion coefficients were found to decrease with increasing crosslink density, while they increased with increasing film thickness. The apparent activation energy of BADGE and BADGE-related compounds was calculated from the diffusion data and were high, in the range of 250–264 kJ mol^− 1. The polarity of the simulant and the polarity of the migrant were found to influence migration. The results can be used to improve existing migration models, and thereby help to reduce migration from packaging into food by using safety-by-design approaches in new product development.

这项研究调查了聚合物罐涂膜的特性（例如厚度和交联密度以及迁移物的类型）如何影响模型迁移物的迁移动力学，从而试图更好地理解，建模和控制迁移过程。四个模型移民使用了大小和极性不同的BADGE（双酚A二缩水甘油醚），BADGE·H ₂ O，cyclo-diBADGE和Uvitex OB。脂肪和水性食品模拟物是在高温（70–130°C）下使用的。发现表观扩散系数随交联密度的增加而降低，而随膜厚度的增加而增加。根据扩散数据计算出BADGE和BADGE相关化合物的表观活化能，表观活化能很高，在250–264 kJ mol ^-1的范围内。。发现模拟物的极性和迁移物的极性会影响迁移。结果可用于改进现有的迁移模型，从而通过在新产品开发中使用按设计安全的方法来帮助减少从包装到食品的迁移。