Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment−specific therapies.

中文翻译：

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重塑肿瘤基质以治疗胰腺癌

胰腺癌伴有纤维化反应，该反应改变了肿瘤细胞与基质之间的相互作用，从而促进了肿瘤的进展。因此，靶向肿瘤基质的策略可用于治疗胰腺癌患者。我们回顾了最近开发的重塑胰腺肿瘤基质的方法，并讨论了这些方法如何改善患者预后。我们还描述了胰腺肿瘤细胞外基质，脉管系统，免疫系统和新陈代谢之间的关系，并讨论了对间质隔室特异性疗法发展的意义。