Abstract This study addresses the challenge of blending poly(vinylidene fluoride) (PVDF) and a zwitterionic copolymer of styrene units, sulfobetaine methacrylate units and ethylene glycol methacrylate units (PS-r-PEGMA-r-PSBMA) to form fouling-resistant membranes in one step. Membranes with a lacy structure were obtained. Fouling tests highlighted the very good efficiency of the copolymer, but the influence of the zwitterionic groups was only seen in harsher conditions: the addition of PSBMA in the copolymer improved the fouling resistance after incubation of the membranes with fibrinogen from platelet-poor-plasma, bacteria or whole blood. The zwitterionic membrane outperformed the commercial hydrophilic PVDF membrane in permeability tests after incubation with a platelet-poor-plasma solution with a FRR of 91% while it was 66% with the commercial membrane. Overall, these results show that using a solubility enhancing block (here PEGMA) can permit to take full advantage of the excellent antifouling properties of zwitterionic materials and readily prepare fouling-resistant membranes in one step.

中文翻译：

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用两性离子共聚物直接原位改性 PVDF 膜，形成双连续和抗污染膜

摘要 本研究解决了将聚偏二氟乙烯 (PVDF) 与苯乙烯单元、磺基甜菜碱甲基丙烯酸酯单元和乙二醇甲基丙烯酸酯单元 (PS-r-PEGMA-r-PSBMA) 的两性离子共聚物共混以形成抗污膜的挑战。一步。获得了具有花边结构的膜。污染测试突出了共聚物的非常好的效率，但两性离子基团的影响仅在更苛刻的条件下才能看到：在共聚物中添加 PSBMA 提高了膜与来自贫血小板血浆的纤维蛋白原孵育后的抗污染性，细菌或全血。在与贫血小板血浆溶液孵育后，两性离子膜在渗透性测试中优于商业亲水性 PVDF 膜，FRR 为 91%，而商业膜为 66%。总体而言，这些结果表明，使用溶解度增强嵌段（此处为 PEGMA）可以充分利用两性离子材料的优异防污性能，并在一步中轻松制备防污膜。