Abstract At present, all electrospraying processes are conducted in air environment without considering the importance of electrohydrodynamic interfaces, thereby preventing the development of new possibilities. In this study, a modified coaxial electrospraying process for preparing multicomponent composite nanoparticles was investigated, in which solvents were explored as the shell working fluids to create dynamic air–solvent solution interfaces. The coaxial process was conducted using a blending solution (comprising hydroxypropyl methylcellulose, paracetamol (APAP), and polyvinylpyrrolidone in a mixture of dichloromethane and ethanol) as the core fluid and a solvent mixture as the shell fluid under a series of shell-to-core fluid flow rate ratios. Results demonstrated that the interface modification by the additional shell solvent generated significant influences on the final particulate multicomponent composites. An exponential relationship between the shell-to-core fluid flow rate ratio (F) and the particle diameters (D, μm) could be determined as D = 0.54 F− 0.39 (| R | = 0.9890). APAP was amorphously distributed within its solid “cocktails” to form a multicomponent nanocomposite. The resultant particles from the modified coaxial process could provide an immediate drug release, with a best value of four times faster than the counterparts from traditional blending electrospraying. The synergistic actions of particle size, amorphous drug status, and combined usage of hydrophilic polymers could ensure the fast dissolution and immediate release of APAP. The protocols reported in this study paved a new way for developing new types of functional nanomaterials via coaxial electrospraying.

中文翻译：

---

通过改变电喷雾过程中的电流体动力学界面制备用于立即释放药物的复合纳米颗粒

摘要 目前，所有的电喷雾过程都是在空气环境中进行的，没有考虑电流体动力学界面的重要性，从而阻碍了新可能性的发展。在这项研究中，研究了一种用于制备多组分复合纳米粒子的改良同轴电喷雾工艺，其中探索了溶剂作为壳工作流体以创建动态空气 - 溶剂溶液界面。使用共混溶液（包括羟丙基甲基纤维素、扑热息痛（APAP）和聚乙烯吡咯烷酮在二氯甲烷和乙醇的混合物中）作为核流体和溶剂混合物作为壳流体在一系列壳对核下进行同轴工艺。流体流速比。结果表明，附加壳溶剂的界面改性对最终的颗粒多组分复合材料产生了显着影响。壳核流体流速比 (F) 和粒径 (D, μm) 之间的指数关系可以确定为 D = 0.54 F- 0.39 (| R | = 0.9890)。APAP 无定形分布在其固体“鸡尾酒”中，形成多组分纳米复合材料。来自改良同轴工艺的所得颗粒可以提供即时药物释放，最佳值比传统混合电喷雾的对应物快四倍。粒径、无定形药物状态和亲水聚合物的联合使用的协同作用可以确保APAP的快速溶解和立即释放。