Abstract Previous studies demonstrated that the antibacterial action of molybdenum disulfide (MoS2) is highly dependent on the light-activated potential of reactive oxygen species (ROS) generation; here vertically aligned molybdenum disulfide nanosheets (MoS2, with or without doping of iron) were coated on titanium (Ti) substrates via a one-step hydrothermal reaction, and their excellent activity against both Escherichia coli (E. coli, ATCC 25922) and Staphylococcus aureus (S. aureus, ATCC 25923) was evidenced under dark conditions. Release of MoO42− and generation of MoS2-inspired ROS were found to be the key factors answering for the bactericidal property of the nanosheets. What’s more, iron-doping in terms of FeMoO4 could boost the antibacterial efficacy further, which stems from quick release of Fe2+ and generation of ROS by Fenton-like reactions. Accordingly, it is believed that the dark antibacterial efficacy of the vertically aligned MoS2 nanosheets is guaranteed by uniting ion release and ROS generation. This study provides new insight into design and application of MoS2 coatings for disinfection of biomedical devices, where light is hard to be served.

中文翻译：

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二硫化钼 (MoS 2 ) 纳米片垂直涂覆在钛上用于黑暗消毒

摘要 以往的研究表明，二硫化钼（MoS2）的抗菌作用高度依赖于活性氧（ROS）产生的光活化电位；这里垂直排列的二硫化钼纳米片（MoS2，掺杂或不掺杂铁）通过一步水热反应涂覆在钛（Ti）基材上，并且它们对大肠杆菌（E.coli，ATCC 25922）和葡萄球菌具有优异的活性金黄色葡萄球菌 (S. aureus, ATCC 25923) 在黑暗条件下被证实。发现 MoO42− 的释放和 MoS2 激发的 ROS 的产生是影响纳米片杀菌性能的关键因素。更重要的是，FeMoO4 方面的铁掺杂可以进一步提高抗菌功效，这源于 Fe2+ 的快速释放和类芬顿反应产生的 ROS。因此，认为垂直排列的 MoS2 纳米片的暗抗菌功效是通过将离子释放和 ROS 生成结合起来保证的。这项研究为 MoS2 涂层的设计和应用提供了新的见解，用于对难以提供光照的生物医学设备进行消毒。