In the loop: We evaluated substitutions of two widely explored classes of cyclic and acyclic β‐amino acid into three different β‐hairpin loop prototypes within a β‐sheet‐rich protein tertiary structure, and identified sequence–structure– stability relationships that should be broadly extensible to future protein design efforts involving these residues.

中文翻译：

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蛋白质环中β-氨基酸置换的评估：对构象稳定性和结构的影响

在循环中：我们评估了两种广泛探索的环状和无环β-氨基酸在富含β-折叠的蛋白质三级结构中被三种不同的β-发夹环原型所取代的可能性，并确定了应该保持的序列-结构-稳定性关系。广泛扩展到涉及这些残基的未来蛋白质设计工作。