Biomaterials for Skin Substitutes,Advanced Healthcare Materials

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Biomaterials for Skin Substitutes
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-12-22 , DOI: 10.1002/adhm.201700897
Mohammadali Sheikholeslam _{1,

2} , Meghan E E Wright ₃ , Marc G Jeschke _{1,

2,

4} , Saeid Amini-Nik _{1,

2,

5}

Affiliation

Patients with extensive burns rely on the use of tissue engineered skin due to a lack of sufficient donor tissue, but it is a challenge to identify reliable and economical scaffold materials and donor cell sources for the generation of a functional skin substitute. The current review attempts to evaluate the performance of the wide range of biomaterials available for generating skin substitutes, including both natural biopolymers and synthetic polymers, in terms of tissue response and potential for use in the operating room. Natural biopolymers display an improved cell response, while synthetic polymers provide better control over chemical composition and mechanical properties. It is suggested that not one material meets all the requirements for a skin substitute. Rather, a composite scaffold fabricated from both natural and synthetic biomaterials may allow for the generation of skin substitutes that meet all clinical requirements including a tailored wound size and type, the degree of burn, the patient age, and the available preparation technique. This review aims to be a valuable directory for researchers in the field to find the optimal material or combination of materials based on their specific application.

中文翻译：

用于皮肤替代品的生物材料

由于缺乏足够的供体组织，大面积烧伤患者依赖于组织工程皮肤的使用，但确定可靠且经济的支架材料和供体细胞来源来生成功能性皮肤替代品是一个挑战。当前的审查试图评估可用于生成皮肤替代品的各种生物材料（包括天然生物聚合物和合成聚合物）在组织反应和在手术室中使用的潜力方面的性能。天然生物聚合物显示出改善的细胞反应，而合成聚合物则可以更好地控制化学成分和机械性能。建议没有一种材料能够满足皮肤替代品的所有要求。相反，由天然和合成生物材料制成的复合支架可以产生满足所有临床要求的皮肤替代品，包括定制的伤口大小和类型、烧伤程度、患者年龄和可用的准备技术。本综述旨在为该领域的研究人员提供有价值的目录，帮助他们根据具体应用找到最佳材料或材料组合。

更新日期：2017-12-22

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