A landscape of commitment

A landscape of commitment, Published online: 22 December 2017; doi:10.1038/s41588-017-0028-1

This issue features epigenetic analysis of cell commitment at many levels in mammalian genomes: during early embryonic development, in stem cells, and in cancer cells. The establishment, propagation and dynamic robustness of cell states is addressed by comprehensive interrogation of the coordination of DNA methylation with the marks and organization of chromatin and programs of gene expression. Understanding this landscape of commitment is essential to interpretation of the functional consequences of genome variation.

中文翻译：

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承诺的风景


承诺的风景

《承诺的风景》，在线发布：2017 年 12 月 22 日； doi:10.1038/s41588-017-0028-1

本期的特点是对哺乳动物基因组中多个水平的细胞定型进行表观遗传学分析：早期胚胎发育期间、干细胞和癌细胞中。细胞状态的建立、传播和动态稳健性是通过全面询问 DNA 甲基化与染色质标记和组织以及基因表达程序的协调来解决的。了解这种承诺景观对于解释基因组变异的功能后果至关重要。