SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η⁶-p-cymene)Cl₂{Ph₂P(CH₂)₃SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential. According to the loaded amount of the [Ru] in SBA-15|[Ru] and SBA-15~SH|[Ru] the IC₅₀ values are 1–2 μM depending on the test used, thus in comparison to [Ru] alone the activity of nanomaterials containing [Ru] are elevated 3–6 times in vitro. However, the mechanism of apoptosis induction differs for these two mesoporous silica. Unlike reference [Ru] compound and SBA-15~SH|[Ru], SBA-15|[Ru] induces high caspase activation. Discrepancy in mechanism of drugs action at intracellular level points towards an influence of functionalization as well as availability of the drug. Moreover, both SBA-15|[Ru] and SBA-15~SH|[Ru] similarly to [Ru] are declining autophagy in B16 cell line.

SBA-15（圣巴巴拉非晶15）中孔二氧化硅和其官能化的形式（与3-巯基丙基）SBA-15〜SH被用作的[Ru（η载体⁶ - p -cymene）氯₂ {博士₂ P（CH ₂）₃ SPH-κ P}]复数，表示为[Ru]。用传统方法表征了制备的介孔二氧化硅纳米材料。没有[Ru]复合物的材料对黑色素瘤B16和B16-F10细胞系没有任何细胞毒活性。相反，含有[Ru]的材料，例如SBA-15 | [Ru]和SBA-15-SH | [Ru]，对测试的肿瘤细胞系表现出非常高的活性，而且具有相似的抑制潜力。根据SBA-15 | [Ru]和SBA-15〜SH | [Ru]中[Ru]的负载量，IC ₅₀取决于所用的测试，其值为1–2μM，因此与单独[Ru]相比，含[Ru]的纳米材料的活性在体外提高了3–6倍。但是，这两种介孔二氧化硅的凋亡诱导机理不同。与参考[Ru]化合物和SBA-15〜SH | [Ru]不同，SBA-15 | [Ru]诱导高胱天蛋白酶激活。在细胞内水平上药物作用机理的差异指向功能性以及药物可用性的影响。另外，类似于[Ru]的SBA-15 | [Ru]和SBA-15_SH | [Ru]在B16细胞系中都在自噬下降。