Although studies have examined leaching of bisphenol A (BPA) from dental sealants into saliva, occurrence of BPA, bisphenol A diglycidyl ether (BADGE), and their derivatives in dental sealants themselves has not been investigated. In this study, concentrations of eight bisphenol analogues (BPs), BADGE and its derivatives (BADGEs), including BADGE‧H₂O, BADGE‧HCl, BADGE‧2H₂O, BADGE‧2HCl, and BADGE‧H₂O‧HCl, were determined in 70 dental sealants collected from the U.S. market. Of the 70 dental sealants analyzed, 65 contained at least one of the target chemicals measured. BADGE‧2H₂O was the most abundant compound, found at concentrations of up to 1780 µg/g. The geometric mean (GM) concentration of total BADGEs was 47.8 µg/g, which was two to three orders of magnitude higher than that of total BPs (GM: 539 ng/g). BPA was found in 46% of the sealants and BADGEs was found in 87% of the sealants analyzed. Majority of the dental sealants analyzed in this study were manufactured in the United States and Korea; no significant differences were observed in the concentrations of BPs and BADGEs between the two countries. An exposure assessment was made based on the concentrations of BPs and BADGEs measured in sealants and their application rates in dentistry. The worst-case exposure scenario with the highest measured concentration of total BPs and BADGEs and application on 8 teeth at 8 mg each yielded an estimated daily intake (EDI) of 1670 and 5850 ng/kg·bw/day for adults and children, respectively. Although the EDI is below the specific migration limit set by the European Food Safety Authority, dental sealants are a source of exposure to BPs and BADGEs, especially in children.

尽管研究已经研究了双酚A（BPA）从牙科密封剂中浸出到唾液中的情况，但尚未研究双酚A，双酚A二缩水甘油醚（BADGE）及其衍生物在牙科密封剂本身中的存在。在这项研究中，八个双酚类似物（BPS）的浓度，BADGE和它的衍生物（徽章），包括BADGE‧H ₂ O，BADGE‧HCl，BADGE‧2H ₂ O，BADGE‧2HCl，和BADGE‧H ₂ O‧HCl是从美国市场收集的70种牙科密封胶中确定的。在分析的70种牙科密封剂中，有65种含有至少一种目标化学物质。BADGE‧2H ₂O是最丰富的化合物，浓度高达1780 µg / g。总BADGE的几何平均（GM）浓度为47.8 µg / g，比总BP的几何平均（GM：539 ng / g）高2至3个数量级。在46％的密封胶中发现了BPA，在87％的密封胶中发现了BADGE。这项研究中分析的大多数牙齿密封剂是在美国和韩国生产的。两国之间的BP和BADGE浓度没有显着差异。根据密封胶中测得的BPs和BADGEs的浓度及其在牙科中的施用量进行暴露评估。在最坏的情况下，测得的总BP和BADGE的浓度最高，并以8 mg的剂量在8颗牙齿上施用，成人和儿童的估计每日摄入量（EDI）分别为1670和5850 ng / kg·bw /天。 。尽管EDI低于欧洲食品安全局设定的特定迁移限制，但牙科密封剂还是BP和BADGE暴露的来源，尤其是在儿童中。