Menopause is a natural event that occurs in women around the age of 50 years, causing irregularities in the menstrual cycle until its complete end, due to the hormonal deficit, especially estrogen, that causes several unpleasant urogenital and vasomotor symptoms. Hormone replacement therapy has many benefits, but should be prescribed with caution in women with a history of stroke, thromboembolic events, certain types of cancer, or increased risk (genetic predisposition) for these events, so many women seek alternatives to hormonal therapy. Phytoestrogens, especially isoflavones, have many benefits in the climacteric phase, due to the similarity of their chemical structure with the hormone estradiol (E2), reducing the rate of menopause side effects and resulting in symptom relief. Furthermore, the isoflavones may still have their effects potentiated by an intestinal microbiota modulated with probiotic strains, which act on metabolism and increase the bioavailability of these phytoestrogens, and can benefit menopausal women's health.

更年期是自然事件，发生在50岁左右的女性中，由于荷尔蒙不足，尤其是雌激素，导致月经周期不规律直至完全结束，这会引起一些不愉快的泌尿生殖道和血管舒缩症状。激素替代疗法有很多好处，但是对于有中风，血栓栓塞事件，某些类型的癌症或这些事件发生风险增加（遗传易感性）的女性，应谨慎服用，因此许多女性寻求激素治疗的替代方法。植物雌激素，尤其是异黄酮，在更年期具有许多好处，因为它们的化学结构与雌二醇（E2）相似，从而降低了更年期副作用的发生率，并减轻了症状。此外，