The effect of red raspberry fruit (RSP) was assessed in obesity-prone, Zucker Fatty rats as a model of cardiometabolic risk. RSP reduced fasting triglycerides and fasting glucose but did not appear to affect fasting insulin, low-density lipoprotein, or body weight gain. RSP did significantly reduce heart rate relative to time-matched CON rats. Noteworthy, RSP reduced left ventricular enlargement and wall thickening as measured by echocardiography, without impacting ejection fraction. Cardiac tissue was also evaluated for relative gene expression of key genes impacted in non-insulin-dependent diabetes mellitus (NIDDM). RSP upregulated the expression of myocardial adiponectin receptor 1 and apolipoprotein E, which may impact plasma cholesterol and triglyceride homeostasis. The lipoprotein lipase (Lpl) gene was down-regulated. On the contrary, RSP did not alter PPAR and NF-kB-related mRNA in heart tissue, but did alter nicotinamide phosphoribosyltransferase (Nampt) mRNA. RSP intake impacted cardiometabolic pathophysiology in this model, and molecular mechanisms deserve further study.

在易肥胖的Zucker Fatty大鼠中评估了红树莓果实（RSP）的作用，将其作为心脏代谢风险的模型。RSP可以降低空腹甘油三酯和空腹血糖，但似乎并未影响空腹胰岛素，低密度脂蛋白或体重增加。相对于时间匹配的CON大鼠，RSP确实显着降低了心率。值得注意的是，通过超声心动图测量，RSP可减少左心室扩大和壁增厚，而不会影响射血分数。还评估了心脏组织中影响非胰岛素依赖型糖尿病（NIDDM）的关键基因的相对基因表达。RSP上调了心肌脂联素受体1和载脂蛋白E的表达，这可能会影响血浆胆固醇和甘油三酸酯的体内平衡。脂蛋白脂肪酶（Lpl）基因被下调。相反，RSP不会改变心脏组织中的PPAR和NF-kB相关mRNA，但是会改变烟酰胺磷酸核糖基转移酶（Nampt）mRNA。RSP摄入量在该模型中影响了心脏代谢的病理生理，其分子机制值得进一步研究。