ROS-Sensitive Polymeric Nanocarriers with Red Light-Activated Size Shrinkage for Remotely Controlled Drug Release,Chemistry of Materials

当前位置： X-MOL 学术 › Chem. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

ROS-Sensitive Polymeric Nanocarriers with Red Light-Activated Size Shrinkage for Remotely Controlled Drug Release
Chemistry of Materials ( IF 7.2 ) Pub Date : 2018-01-08 00:00:00 , DOI: 10.1021/acs.chemmater.7b04751
Ziyang Cao _{1,

2} , Yinchu Ma ₂ , Chunyang Sun ₃ , Zidong Lu ₁ , Zeyu Yao ₄ , Junxia Wang ₁ , Dongdong Li ₁ , Youyong Yuan ₁ , Xianzhu Yang ₁

Affiliation

Drug delivery systems with remotely controlled drug release capability are rather attractive options for cancer therapy. Herein, a reactive oxygen species (ROS)-sensitive polymeric nanocarrier [email protected]_Ce6/DOX was explored to realize remotely controlled drug release by light-activated size shrinkage. The [email protected]_Ce6/DOX encapsulating chlorin e6 (Ce6) and doxorubicin (DOX) was self-assembled from an innovative ROS-sensitive polymer TK-PPE with the assistance of an amphiphilic copolymer poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL). Under the 660 nm red light irradiation, ROS generated by the encapsulated Ce6 were capable of cleaving the TK linker in situ, which resulted in the rapid degradation of the [email protected]_Ce6/DOX core. Consequently, the size of [email protected]_Ce6/DOX shrank from 154 ± 4 nm to 72 ± 3 nm, and such size shrinkage affected further triggered rapid DOX release. As evidenced by both in vitro and in vivo experiments, such ROS-sensitive polymeric nanocarriers with light-induced size shrinkage capability offer remarkable therapeutic effects in cancer treatment. This concept provides new avenues for the development of light-activated drug delivery systems for remotely controlled drug release in vivo.

中文翻译：

ROS敏感的聚合物纳米载体，具有红光激活的尺寸收缩功能，可用于远程控制药物释放。

具有遥控药物释放能力的药物输送系统是用于癌症治疗的颇具吸引力的选择。在本文中，对活性氧（ROS）敏感的聚合物纳米载体[电子邮件保护] _{Ce6 / DOX}进行了研究，以通过光激活的尺寸收缩实现远程控制的药物释放。受电子邮件保护的_{Ce6 / DOX}包封二氢卟酚e6（Ce6）和阿霉素（DOX）是在两亲共聚物聚（乙二醇）-b -poly（ ε-己内酯）（PEG- b - PCL）。在660 nm红光照射下，包封的Ce6生成的ROS能够原位切割TK连接子，这导致[受电子邮件保护的] _{Ce6 / DOX}核心迅速退化。因此，[受电子邮件保护的] _{Ce6 / DOX}的尺寸从154±4 nm缩小到72±3 nm，这种尺寸收缩影响进一步触发了DOX的快速释放。如体外和体内实验所证明的那样，具有光诱导的尺寸收缩能力的这种ROS敏感的聚合物纳米载体在癌症治疗中提供了显着的治疗效果。该概念为开发用于体内远程控制药物释放的光活化药物递送系统提供了新途径。

更新日期：2018-01-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11