Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents,Green Chemistry

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Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents
Green Chemistry ( IF 9.3 ) Pub Date : 2017-12-22 00:00:00 , DOI: 10.1039/c7gc03191b
Yongqiang Zhang _{1,

2,

3,

4,

5} , Phongphat Prawang _{1,

2,

3,

4,

5} , Chunshan Li _{1,

2,

3,

4,

5} , Xiangzhan Meng _{1,

2,

3,

4,

5} , Yu Zhao _{6,

7,

8,

9} , Hui Wang _{1,

2,

3,

4,

5} , Suojiang Zhang _{1,

2,

3,

4,

5}

Affiliation

Artemisinin is a kind of natural antimalarial drug exhibiting low toxicity and a very fast action against malaria. Solvent extraction is the most widely used method to separate artemisinin from the Chinese medicinal herb Artemisia annua L. In this study, a series of monoether-based solvents were investigated to extract artemisinin, and propylene glycol methyl ether (PGME) was found to be the most appropriate one for this extraction. Ultrasonic irradiation was demonstrated to be able to assist artemisinin extraction. Influence of extraction conditions, including liquid/solid ratio, extraction temperature, ultrasonic time, and ultrasonic power, on the extraction efficiency were discussed by single-factor experiments, and the main influencing factors were optimized by response surface methods. The extraction mechanism was explored using spectroscopic characterizations, and kinetics of this process was also studied. Results indicated that ultrasonic assisted extraction using PGME had faster extraction rate than conventional solvents, and ultrasonic could significantly enhance mass transfer. Compared with conventional extraction, the process developed here exhibited a higher efficiency (13.79 mg g⁻¹vs. 13.29 mg g⁻¹) and shorter extraction time (decreased from 8 h to 0.5 h) at a relatively low temperature. In addition, PGME had low toxicity and volatility, making the extraction process more safe and reliable. Therefore, this proposed method demonstrated that PGME-based ultrasonic assisted extraction is a rapid, efficient, simple and safe technique for natural product extraction.

中文翻译：

使用单醚基溶剂超声辅助从青蒿中提取青蒿素

青蒿素是一种天然的抗疟疾药物，具有低毒性和非常快速的抗疟疾作用。溶剂萃取是从中草药青蒿中分离青蒿素的最广泛方法L.在这项研究中，研究了一系列基于单醚的溶剂提取青蒿素，并且发现丙二醇甲醚（PGME）是最合适的提取方法。超声辐射被证明能够辅助青蒿素的提取。通过单因素实验探讨了液固比，提取温度，超声时间，超声功率等提取条件对提取效率的影响，并通过响应面法优化了主要影响因素。使用光谱表征探索了萃取机理，并且还研究了该过程的动力学。结果表明，使用PGME进行超声辅助萃取比常规溶剂萃取速度更快，超声波可以显着增强传质。与常规提取相比，此处开发的方法显示出更高的效率（13.79 mg g^-1对13.29 mg g^-1）和较短的提取时间（从8 h减少到0.5 h）在相对较低的温度下。此外，PGME的毒性和挥发性低，使提取过程更加安全可靠。因此，该方法证明基于PGME的超声辅助提取是一种快速，高效，简单和安全的天然产物提取技术。

更新日期：2018-02-06

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