Therapeutic applications of iron oxide based nanoparticles in cancer: basic concepts and recent advances,Biomaterials Science

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Therapeutic applications of iron oxide based nanoparticles in cancer: basic concepts and recent advances
Biomaterials Science ( IF 5.8 ) Pub Date : 2017-12-22 00:00:00 , DOI: 10.1039/c7bm00999b
Madiha Saeed _{1,

2,

3,

4,

5} , Wenzhi Ren _{1,

2,

3,

4,

5} , Aiguo Wu _{1,

2,

3,

4,

5}

Affiliation

Nanotechnology has introduced new techniques and phototherapy approaches to fabricate and utilize nanoparticles for cancer therapy. These phototherapy approaches, such as photothermal therapy (PTT) and photodynamic therapy (PDT), hold great promise to overcome the limitations of traditional treatment methods. In phototherapy, magnetic iron oxide nanoparticles (IONPs) are of paramount importance due to their wide range of biomedical applications. This review discusses the basic concepts, various therapy approaches (PTT, PDT, magnetic hyperthermia therapy (MHT), chemotherapy and immunotherapy), intrinsic properties, and mechanisms of cell death of IONPs; it also provides a brief overview of recent developments in IONPs, with focus on their therapeutic applications. Much attention is devoted to elaborating the various parameters, intracellular behaviors and limitations of MHT. Bimodal therapies which act alone or in combination with other modalities are also discussed. The review highlights some limitations in the explored research areas and suggests future directions to overcome these limitations.

中文翻译：

氧化铁基纳米粒子在癌症中的治疗应用：基本概念和最新进展

纳米技术引入了新技术和光疗方法来制造和利用纳米颗粒进行癌症治疗。这些光疗方法，例如光热疗法（PTT）和光动力疗法（PDT），有望克服传统疗法的局限性。在光疗中，磁性氧化铁纳米粒子（IONPs）由于其广泛的生物医学应用而极为重要。这篇综述讨论了IONPs的基本概念，各种治疗方法（PTT，PDT，磁热疗法（MHT），化学疗法和免疫疗法），内在特性和IONPs细胞死亡的机制。它还简要概述了IONP的最新发展，重点是它们的治疗应用。许多注意力都集中在详细说明各种参数上，细胞内行为和MHT的局限性。还讨论了单独或与其他方式结合起作用的双峰疗法。该评论突出了所研究领域的一些局限性，并提出了克服这些局限性的未来方向。

更新日期：2017-12-22

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