Synthesis ( IF 2.2 ) Pub Date : 2017-12-21 , DOI: 10.1055/s-0036-1591866 Isamu Shiina , Yuma Umezaki , Takatsugu Murata , Kyohei Suzuki , Takayuki Tonoi
Abstract
In this paper, we report the first total synthesis of (+)-coprophilin, an anticoccidial agent, by constructing the chiral linear precursor via a Mukaiyama–Evans aldol reaction and a stereoselective intramolecular Diels–Alder reaction. The proposed method can be used to provide large amounts of (+)-coprophilin, which exhibits a 3,4,5,6,7-pentasubstituted Δ1,2-octalin core structure.
In this paper, we report the first total synthesis of (+)-coprophilin, an anticoccidial agent, by constructing the chiral linear precursor via a Mukaiyama–Evans aldol reaction and a stereoselective intramolecular Diels–Alder reaction. The proposed method can be used to provide large amounts of (+)-coprophilin, which exhibits a 3,4,5,6,7-pentasubstituted Δ1,2-octalin core structure.
中文翻译:
(+)-coprophilin的不对称全合成
摘要
在本文中,我们通过Mukaiyama–Evans aldol反应和立体选择性分子内Diels–Alder反应构建手性线性前体,从而报告了抗球虫剂(+)-coprophilin的第一个全合成。所提出的方法可以用于提供大量的(+) -对coprophilin,它显示出3,4,5,6,7-五取代Δ 1,2 -octalin芯结构。
在本文中,我们通过Mukaiyama–Evans aldol反应和立体选择性分子内Diels–Alder反应构建手性线性前体,从而报告了抗球虫剂(+)-coprophilin的第一个全合成。所提出的方法可以用于提供大量的(+) -对coprophilin,它显示出3,4,5,6,7-五取代Δ 1,2 -octalin芯结构。