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Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2017-12-21 , DOI: 10.1016/j.bmcl.2017.12.045
Jun-Jun Qin , Ze-Min Lin , Yan-Sheng Xu , Ji-Wen Ren , Jian-Ping Zuo , Wei-Min Zhao

Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides (14), named periplosides W-Y and 3-O-formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides (14) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A.



中文翻译:

含基孕甾苷螺环从的根皮杠黄花及其抑制活性对B和T淋巴细胞的增殖

的根皮的植物化学研究杠金花茶导致了四个新的含螺环孕甙(阐明DS姚,XC Chen等人JW(萝藦科)1 - 4名为periplosides WY和3-)Ø甲酰基periploside F.在广泛的光谱分析的基础上阐明了它们的结构。四个新孕甙(1 - 4)被发现对B和T淋巴细胞和有利的选择指数的增殖媲美环孢菌素A表现出显著抑制活性

更新日期:2017-12-21
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