The Rhizome of Ligusticum chuanxiong Hort, a traditional Chinese medicine, is widely used to treat cardiovascular diseases and attenuate oxidative stress. The main bioactive compounds including tetramethylpyrazine (TMP), polyphenols, ferulic acid have been reported to be responsible for these effects. This study was to evaluate the influence of Ligusticum chuanxiong extraction (LCE) in mimic gastrointestinal tract on antioxidant activity. The effects of gastric digestion group metabolic liquid on free radical scavenging followed as DPPH > ·O²⁻ > ·OH, while the clearance effects of intestine digestion group expressed as ·O²⁻> ·OH > DPPH. Furthermore, the digested extraction promoted lower cellular antioxidant activity (CAA) with dose-response correlations. Gastrointestinal digestion increased the release of bound ferulic acids and polyphenols. Content of ferulic acid in gastric and intestinal metabolic solution increased from 6.07 mg/g to 9.33 mg/g and 14.17 mg/g. The free phenolic before and after digestion were 177.38 mg/g, 179.69 mg/g and 194.99 mg/g, respectively. The simulated gastrointestinal digestion of LCE promoted a significant increase in the free phenolic acids content, antioxidant activity and CAA.

中药川Hor的根茎被广泛用于治疗心血管疾病和减轻氧化应激。据报道，主要的生物活性化合物包括四甲基吡嗪（TMP），多酚，阿魏酸是造成这些作用的原因。本研究旨在评价川gust提取物（LCE）在模拟胃肠道中对抗氧化活性的影响。胃消化组代谢液对自由基清除的影响依次为DPPH>·O ²⁻  >·OH，而肠消化组的清除作用表示为·O ²⁻>·OH> DPPH。此外，消化提取物促进了较低的细胞抗氧化剂活性（CAA），并具有剂量反应相关性。胃肠道消化增加了结合的阿魏酸和多酚的释放。胃和肠代谢溶液中的阿魏酸含量从6.07 mg / g增加到9.33 mg / g和14.17 mg / g。消化前后的游离酚含量分别为177.38 mg / g，179.69 mg / g和194.99 mg / g。LCE的模拟胃肠道消化促进游离酚酸含量，抗氧化活性和CAA的显着增加。