In 2016, the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) network proposed modifications to the MRI criteria to define dissemination in space (DIS) and time (DIT) for the diagnosis of multiple sclerosis in patients with clinically isolated syndrome (CIS). Changes to the DIS definition included removal of the distinction between symptomatic and asymptomatic lesions, increasing the number of lesions needed to define periventricular involvement to three, combining cortical and juxtacortical lesions, and inclusion of optic nerve evaluation. For DIT, removal of the distinction between symptomatic and asymptomatic lesions was suggested. We compared the performance of the 2010 McDonald and 2016 MAGNIMS criteria for multiple sclerosis diagnosis in a large multicentre cohort of patients with CIS to provide evidence to guide revisions of multiple sclerosis diagnostic criteria.

中文翻译：

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使用2016 MAGNIMS和2010 McDonald标准对临床孤立综合征患者的多发性硬化症诊断进行预测：一项回顾性研究。

2016年，多发性硬化症磁共振成像（MAGNIMS）网络提出了对MRI标准的修改，以定义空间传播（DIS）和时间（DIT），以诊断患有临床孤立综合征（CIS）的多发性硬化症。DIS定义的改变包括消除有症状和无症状病变之间的区别，将定义脑室周围病变所需的病变数量增加到三个，将皮质和近皮质病变结合起来，并纳入视神经评估。对于DIT，建议消除有症状和无症状病变之间的区别。