The field of multiple sclerosis has undergone astounding changes over the past three decades. Many developments are the result of MRI, which has improved multiple sclerosis diagnosis and enhanced clinical trial outcome measures. The term clinically isolated syndrome describes a first symptomatic episode of CNS demyelination that might later develop into multiple sclerosis. Improving the imaging criteria to predict conversion to clinically definite multiple sclerosis has been a major, collaborative research effort.

中文翻译：

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完善使用MRI预测多发性硬化症

在过去的三十年中，多发性硬化症领域发生了惊人的变化。MRI带来了许多进展，MRI改善了多发性硬化症的诊断并增强了临床试验结果指标。术语“临床孤立综合征”描述了中枢神经系统脱髓鞘的第一个症状发作，随后可能发展为多发性硬化症。改善成像标准以预测转化为临床上确定的多发性硬化症是一项重大的合作研究工作。