Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides,Chemical Communications

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Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
Chemical Communications ( IF 4.3 ) Pub Date : 2017-12-21 00:00:00 , DOI: 10.1039/c7cc08286j
David Bouzada _{1,

2,

3,

4,

5} , Iria Salvadó _{1,

2,

3,

4,

6} , Ghofrane Barka _{1,

2,

3,

4,

6} , Gustavo Rama _{1,

2,

3,

4,

6} , José Martínez-Costas _{1,

2,

3,

4,

7} , Romina Lorca _{4,

8,

9,

10} , Álvaro Somoza _{4,

8,

9,

10} , Manuel Melle-Franco _{11,

12,

13,

14} , M. Eugenio Vázquez _{1,

2,

3,

4,

5} , Miguel Vázquez López _{1,

2,

3,

4,

6}

Affiliation

A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.

中文翻译：

寡精氨酸-Ru（dppz）金属肽的选择性G-四链体结合

使用SPPS方法已合成了一组含dppz配体的Ru（II）金属肽。荧光滴定研究表明，那些具有八精氨酸尾巴的金属肽对DNA G-四链体结构的结合偏好要强于其，而在其识别中，八肽精氨酸官能化与辅助配体之间的相互作用在识别中起着至关重要的作用。过程。此外，低聚精氨酸金属肽也被有效地内在化，引起具有细胞凋亡迹象的细胞死亡。

更新日期：2018-01-16

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