Quercetin Attenuates Ethanol‐Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II‐L‐Type Calcium Channel,Molecular Nutrition & Food Research

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Quercetin Attenuates Ethanol‐Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II‐L‐Type Calcium Channel
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-02-19 , DOI: 10.1002/mnfr.201700772
Xiaoping Guo _{1,

2,

3} , Man Chen ₄ , Hongmei Zeng _{1,

2,

3} , Peiyi Liu _{1,

2,

3} , Xinghong Zhu _{1,

2,

3} , Feng Zhou _{1,

2,

3} , Jingjing Liu _{1,

2,

3} , Jun Zhang ₁ , Zhuangzhuang Dong ₁ , Yuhan Tang _{1,

2,

3} , Chao Gao ₅ , Ping Yao _{1,

2,

3}

Affiliation

Increased iron deposition in the myocardium in alcoholics may lead to increased risk of cardiac dysfunction. Quercetin has been demonstrated to quench production of intracellular free iron‐induced –OH, but the effect of quercetin in ethanol‐induced cardiac damage remains unclear. This study aims to explore whether quercetin attenuates ethanol‐induced iron uptake and myocardial injury by regulating angiotensin II‐L‐type voltage‐dependent Ca2+ channel (Ang II‐LTCC).

中文翻译：

槲皮素通过调节血管紧张素II-L型钙通道来减轻乙醇诱导的铁摄取和心肌损伤

酗酒者心肌中铁沉积的增加可能导致心脏功能障碍的风险增加。槲皮素已被证明可以猝灭细胞内游离铁诱导的–OH，但槲皮素在乙醇诱导的心脏损伤中的作用尚不清楚。这项研究旨在探讨槲皮素是否通过调节血管紧张素II-L型电压依赖性Ca2 +通道（Ang II-LTCC）来减轻乙醇诱导的铁摄取和心肌损伤。

更新日期：2018-02-19

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