Perfluorocarbons are omniphobic compounds as a consequence of their unique properties such as, e.g., high electronegativity, low polarizability, high ionization energy, and low surface tension. The possibility of combining such properties with the features of nanoscale materials promoted a recent upsurge in the production of fluorinated nanoparticles for application in different fields. Attainment of mixed fluorinated/hydrogenated stabilizing layers is also desired in some cases, but often the composition of the ligand mixture used in the exchange reaction is not reflected in the resulting monolayer. Thus, methodologies for determining the resulting chemical composition of the final mixed fluorinated/hydrogenated monolayers grafted on the nanoparticle (NP) surface are needed. Here we propose a combined Fourier Transform Infrared (FTIR) and X-ray Photoemission Spectroscopy (XPS) investigation for assessing the final chemical composition of a mixed monolayer of hydrogenated and fluorinated alkanethiols grafted on the surface of gold NPs obtained through two different synthetic routes. This analysis allowed the evaluation of the exchange efficiency of the two synthetic routes, and also, coupled with UV–vis studies, highlighted that the colloidal stability of the final NPs was not only dependent on the fluorinated/hydrogenated ratio but also on the chosen exchange route, which seems to influence the ligand organization on the mixed monolayer.

全氟化碳由于其独特的特性（例如：，高电负性，低极化率，高电离能和低表面张力。将这些特性与纳米级材料的特征相结合的可能性促进了用于不同领域的氟化纳米颗粒的生产近来的高涨。在某些情况下，也需要达到混合的氟化/氢化稳定层，但是交换反应中使用的配体混合物的组成通常不会反映在所得的单层中。因此，需要用于确定接枝在纳米颗粒（NP）表面上的最终的混合的氟化/氢化单层的所得化学组成的方法。在这里，我们提出了傅里叶变换红外（FTIR）和X射线光电子能谱（XPS）的组合研究，以评估通过两种不同合成途径获得的接枝在金纳米颗粒表面的氢化和氟化链烷硫醇的混合单层的最终化学组成。这项分析可以评估两种合成途径的交换效率，并且与紫外可见研究相结合，强调了最终NP的胶体稳定性不仅取决于氟化/氢化比率，还取决于所选择的交换途径，似乎影响混合单层上的配体组织。