Periosteum Extracellular‐Matrix‐Mediated Acellular Mineralization during Bone Formation,Advanced Healthcare Materials

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Periosteum Extracellular‐Matrix‐Mediated Acellular Mineralization during Bone Formation
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-12-21 , DOI: 10.1002/adhm.201700660
Xianfeng Lin ₁ , Chenchen Zhao ₁ , Peizhi Zhu ₂ , Jiaxin Chen ₁ , Huaguang Yu ₂ , Yin Cai ₂ , Qi Zhang ₁ , An Qin ₃ , Shunwu Fan ₁

Affiliation

Cell‐mediated mineralization is essential for bone formation and regeneration. In this study, it is proven that extracellular matrix (ECM) of decellularized periosteum can play an initiative and independent role in bone‐like apatite formation. Using decellularized periosteum scaffold, it is revealed that ECM scaffold itself can promote critical bone defect regeneration and nude mouse ectopic ossification. The natural collagen matrix of decellularized periosteum can serve as a 3D structural template for Ca–P nuclei initiation, controlling the size and orientation of bone‐like mineral crystals. The naturally cross‐linked and highly ordered 3D fibrillar network of decellularized periosteum not only provides a model for mimicking mineralization in vitro and in vivo to elucidate the important functions of ECM in bone formation and regeneration, but also can be a promising biomaterial for bone tissue engineering and clinical application.

中文翻译：

骨形成过程中骨膜细胞外基质介导的细胞矿化

细胞介导的矿化对于骨骼形成和再生至关重要。在这项研究中，已证明脱细胞的骨膜的细胞外基质（ECM）可以在骨样磷灰石的形成中发挥主动和独立的作用。使用脱细胞的骨膜支架，可以发现ECM支架本身可以促进关键的骨缺损再生和裸鼠异位骨化。脱细胞骨膜的天然胶原蛋白基质可作为Ca–P核起始的3D结构模板，控制骨样矿物晶体的大小和方向。脱细胞骨膜的天然交联且高度有序的3D纤维状网络不仅提供了在体外和体内模拟矿化的模型，从而阐明了ECM在骨骼形成和再生中的重要功能，

更新日期：2017-12-21

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