An efficient nickel‐catalyzed Heck‐type reaction between styrenes and fluoroalkyl iodine has been developed. This novel transformation has demonstrated a broad substrate scope, mild reaction conditions and excellent E‐stereoselectivity. This efficient synthetic method has been applied to the late‐stage monofluoroacetation of biologically active molecules. Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.

中文翻译：

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苯乙烯催化的镍催化的Heck型单氟乙酰化，可轻松合成烯丙基氟化物

已经开发出一种有效的镍催化苯乙烯与氟代烷基碘之间的Heck型反应。这种新颖的转化证明了广泛的底物范围，温和的反应条件和出色的E-立体选择性。这种有效的合成方法已应用于生物活性分子的后期单氟乙酰化。机理研究表明，一氟烷基参与了催化循环。