Implantable and Biodegradable Poly(l‐lactic acid) Fibers for Optical Neural Interfaces,Advanced Optical Materials

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Implantable and Biodegradable Poly(l‐lactic acid) Fibers for Optical Neural Interfaces
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2017-12-21 , DOI: 10.1002/adom.201700941
Ruxing Fu _{1,

2} , Wenhan Luo _{3,

4,

5} , Roya Nazempour ₁ , Daxin Tan ₂ , He Ding ₁ , Kaiyuan Zhang _{1,

2} , Lan Yin ₂ , Jisong Guan _{5,

6} , Xing Sheng ₁

Affiliation

Advanced optical fibers and photonic structures play important roles in neuroscience research, along with recent progresses of genetically encoded optical actuators and indicators. Most techniques for optical neural implants rely on fused silica or long‐lasting polymeric fiber structures. In this paper, implantable and biodegradable optical fibers based on poly(l‐lactic acid) (PLLA) are presented. PLLA fibers with dimensions similar to standard silica fibers are constructed using a simple thermal drawing process at around 220 °C. The formed PLLA fibers exhibit high mechanical flexibility and optical transparency, and their structural evolution and optical property changes are systematically studied during in vitro degradation. In addition, their biocompatibility with brain tissues is evaluated in living mice, and full in vivo degradation is demonstrated. Finally, PLLA fibers are implemented as a tool for intracranial light delivery and detection, realizing deep brain fluorescence sensing and optogenetic interrogation in vivo. The presented materials and device platform offer paths to fully biocompatible and bioresorbable photonic systems for biomedical uses.

中文翻译：

用于光学神经界面的可植入和可生物降解的聚（l-乳酸）纤维

先进的光纤和光子结构，以及遗传编码的光学致动器和指示器的最新进展，在神经科学研究中都发挥着重要作用。大多数用于光学神经植入物的技术都依赖于熔融石英或持久的聚合物纤维结构。在本文中，基于聚（l）的可植入和可生物降解的光纤‐乳酸）（PLLA）。尺寸类似于标准二氧化硅纤维的PLLA纤维是通过简单的热拉伸工艺在约220°C下构建的。形成的PLLA纤维具有很高的机械柔韧性和光学透明性，并且在体外降解过程中系统地研究了它们的结构演变和光学性质变化。另外，在活小鼠中评估了它们与脑组织的生物相容性，并证明了其在体内的完全降解。最后，PLLA纤维可作为颅内光传递和检测的工具，在体内实现深层脑部荧光感测和光遗传学探究。提出的材料和设备平台为生物医学用途提供了完全生物相容和可生物吸收的光子系统的途径。

更新日期：2017-12-21

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