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Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2017-12-21 , DOI: 10.1016/j.chembiol.2017.11.009
Jing Tang 1 , Zia-Ur-Rehman Tanoli 2 , Balaguru Ravikumar 2 , Zaid Alam 2 , Anni Rebane 2 , Markus Vähä-Koskela 2 , Gopal Peddinti 2 , Arjan J van Adrichem 2 , Janica Wakkinen 2 , Alok Jaiswal 2 , Ella Karjalainen 2 , Prson Gautam 2 , Liye He 2 , Elina Parri 2 , Suleiman Khan 2 , Abhishekh Gupta 2 , Mehreen Ali 2 , Laxman Yetukuri 2 , Anna-Lena Gustavsson 3 , Brinton Seashore-Ludlow 3 , Anne Hersey 4 , Andrew R Leach 4 , John P Overington 5 , Gretchen Repasky 2 , Krister Wennerberg 2 , Tero Aittokallio 1
Affiliation  

Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioactivity data resources are often incomparable due to non-standardized and heterogeneous assay types and variability in endpoint measurements. To extract higher value from the existing and future compound target-profiling data, we implemented an open-data web platform, named Drug Target Commons (DTC), which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration. We demonstrate the unique value of DTC with several examples related to both drug discovery and drug repurposing applications and invite researchers to join this community effort to increase the reuse and extension of compound bioactivity data.

中文翻译:


药物靶标共享:社区努力建立药物-靶标相互作用的共识知识库



了解生物活性物质、已批准和研究药物以及化学探针的完整靶点空间,可以为治疗潜力和可能的不良反应提供重要的见解。由于非标准化和异构检测类型以及终点测量的可变性,现有的化合物靶标生物活性数据资源通常无法比较。为了从现有和未来的化合物靶标分析数据中提取更高的价值,我们实施了一个名为 Drug Target Commons (DTC) 的开放数据网络平台,该平台具有用于众包化合物靶标生物活性数据注释、标准化、管理、以及内部资源整合。我们通过与药物发现和药物再利用应用相关的几个例子展示了 DTC 的独特价值,并邀请研究人员加入这个社区的努力,以增加化合物生物活性数据的重用和扩展。
更新日期:2018-02-15
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